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計畫

負責人

計畫重點

計畫總主持人

子計畫一

謝茂志

余信賢

何秉穎

Preclinical evaluate  the effcacy of neoadjuvant and pharmacologic synergistic treatments with HIPEC by patient-derived xenograft models in gastric cancer peritoneal metastases.

子計畫二

張宜崴

何秉穎

Identifying novel predicted cargoes via extracellular vesicles to monitoring the clinical outcomes of HIPEC in gastric cancer peritoneal metastases.

子計畫三

戴裕庭

張偉嶠

劉承賢

何秉穎

Investigating the novel therapeutic strategies association of genetic variants to monitoring the clinical outcomes of HIPEC in gastric cancer peritoneal metastases.

子計畫四

藺瑞安

何秉穎

Investigating the perioperative events associated with the outcomes of HIPEC in gastric cancer peritoneal metastasis.

 

研究主題:改善溫熱化學治療胃癌腹膜轉移之新策略

研究摘要

 

     Peritoneal metastasis as a result of the dissemination of gastrointestinal or gynecological cancer into the peritoneal cavity and often associated with disease progression and poor prognosis. At the Ninth International Congress on Peritoneal Surface Malignancies held in Amsterdam, the Netherlands, 2014, the Peritoneal Surface Oncology Group International officially proposed the International Recommendations for Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) as the standard treatment for appendiceal mucinous cancer, colorectal peritoneal metastasis, and malignant peritoneal mesothelioma, and it is a recommended therapy for ovarian cancer and gastric cancer with peritoneal metastasis. Unfortunately, among the peritoneal metastasis derived from different gastrointestinal cancers, gastric cancer peritoneal metastasis had the lowest 5-years survival rate following CRS/HIPEC. Therefore, it is necessary to carry out a strictly designed prospective clinical study on gastric cancer peritoneal metastasis to improve the treatment strategy and efficacy and to promote the comprehensive treatment approach in clinical oncology.